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Pulmonary hypertension is a life-threatening disease with no known cure. Here we provide a concise yet comprehensive review of the current knowledge about the pathophysiology of pulmonary hypertension (PH). The underlying signaling mechanisms involved in pulmonary vascular remodeling and the exaggerated vascular contractility, two characteristic features of pulmonary hypertension, are discussed in depth. The roles of inflammation, immunity, and right ventricular function in the pathobiology of pulmonary hypertension are discussed. The epidemiology of the five groups of pulmonary hypertension (World Health Organization classification; Nice, 2013) is also briefly described. A clear understanding of our current knowledge about the pathogenesis of PH is essential for further exploration of the underlying mechanisms involved in this disease and for the development of new therapeutic modalities. This book should be of interest to researchers and graduate students, both in basic research and in clinical settings, in the fields of pulmonary vascular biology and pulmonary hypertension.
Acerca de Yuansheng Gao
Yuansheng Gao, Ph.D., received his Ph.D. in Physiology (1990; advisor: Paul M. Vanhoutte) from Mayo Graduate School, Rochester, Minnesota and postdoctoral training in Professor Vanhoutte’s laboratory at the Baylor College of Medicine, Houston, Texas (1990–1992). He worked in Professor J. Usha Raj’s laboratory from 1992 to 2002 as an Adjunct Assistant/Associate Professor at Harbor-UCLA Medical Center, Los Angeles, California. Since 2002 he serves as Professor of Pathophysiology in Peking University Health Science Center, Beijing, China. He has been an Honorary Professor of Department of Pharmacology and Pharmacy in the University of Hong Kong, China since 2014. He has served as the council member of Asian Society for Vascular Biology since 2005 and the review editor for the journal Frontiers in Vascular Physiology since 2011. He has worked on the signaling transduction of pulmonary and coronary vasculature for nearly 30 years and has published over 90 original research and review articles in this field.
Acerca de J. Usha Raj
J. Usha Raj, M.D., is the Anjuli S. Nayak Professor of Pediatrics, University of Illinois, Chicago, Illinois. She was the Head of Pediatrics at UIC from 2008 to 2015 and Chief of Neonatology at Harbor-UCLA from 1995 to 2008. Dr. Raj is nationally and internationally known as a clinician-scientist for her research on the mechanisms involved in the development of pulmonary hypertension. Her work has been funded by the National Institutes of Health (NIH) for over 32 years. She is a co-investigator on grants funded by the NIH and Center for Medicare and Medicaid that are designed to improve care for the underserved pediatric population in Chicago. She has published over 165 peer-reviewed scientific manuscripts in high-quality journals. She has received numerous awards from International Scientific Societies, including the Scientific Recognition and Distinguished Achievement Awards from the American Thoracic Society and the Julius Comroe Jr. Distinguished Lectureship and election as a fellow to the society by the American Physiological Society. She received an honorary doctorate (honoris causa) from the University of Lausanne in June 2016 in recognition of her many contributions in research and mentorship. She is a member of the World Task Force on Pediatric Pulmonary Hypertension and an advisor to the Pediatric Pulmonary Hypertension network in North America. She has been selected for the “U.S. News & World Report” Top Doctors list.
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